小儿肺咳颗粒联合氨溴特罗口服溶液治疗小儿急性支气管炎临床研究
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R725.6

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Clinical Study on Xiao'er Feike Granules Combined with Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution for Acute Children Bronchiolitis
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    摘要:

    目的:观察小儿肺咳颗粒联合氨溴特罗口服溶液治疗小儿急性支气管炎的临床疗效。方法:选取急性支气管炎患儿116 例,按随机数字表法分为对照组及治疗组,各58 例。对照组采用氨溴特罗口服溶液治疗,治疗组在对照组基础上给予小儿肺咳颗粒治疗。比较2 组患儿治疗前后血清炎症因子、肺功能指标[第1 秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气流量峰值(PEF)] 以及治疗后临床疗效、症状消失时间及不良反应发生情况。结果:治疗后,2组超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、白细胞介素-18 (IL-18) 指标值均较治疗前下降(P<0.05),治疗组上述4 项指标值均低于对照组(P<0.05)。治疗后,2 组FEV1/FVC 及PEF 水平均较治疗前上升(P<0.05),治疗组上述2 项水平均高于对照组(P<0.05)。治疗后,治疗组体温恢复时间、咳嗽消失时间、肺部啰音消失时间均小于对照组,差异均有统计学意义(P<0.05)。治疗后,治疗组总有效率为93.10%,对照组总有效率为70.69%,2 组比较,差异有统计学意义(P<0.05)。治疗2 周后,治疗组不良反应发生率为10.34%,对照组不良反应发生率为27.59%,2 组比较,差异有统计学意义(P<0.05)。结论:急性支气管炎患儿选用小儿肺咳颗粒联合氨溴特罗口服溶液治疗,可缓解临床症状,改善患儿呼吸道炎症反应及肺功能,缩短患儿病程。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Xiao'er Feike granules combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution for acute children bronchiolitis. Methods:A total of 116 cases of children with acute bronchiolitis were divided into the control group and the treatment group according to the random number table method, 58 cases in each group. The control group was treated with ambroxol hydrochloride and clenbuterol hydrochloride oral solution,and the treatment group was additionally treated with Xiao'er Feike granules based on the treatment of the control group. Serum inflammatory factors and indexes of the lung function[Forced inspiratory volume in the first second(FEV1), forced vital capacity(FVC),peak expiratory flow(PEF)] before and after treatment,as well as total curative effects,symptom disappearance time and incidence of adverse reactions after treatment were compared between the two groups. Results: After treatment,hs-CRP,TNF-α,IL-6 and IL-18 in the two groups were decreased when compared with those before treatment(P<0.05),and the four indexes above in the treatment group were lower than those in the control group(P<0.05). After treatment,levels of FEV1/FVC and PEF in the two groups were increased when compared with those before treatment (P<0.05), and the above two levels in the treatment group were higher than those in the control group(P<0.05). After treatment,the recovery time of temperature,as well as the disappearance time of cough and lung rales in the treatment group were earlier than those in the control group,differences being significant(P<0.05). After treatment,the total effective rate was 93.10% in the treatment group and 70.69% in the control group, the difference being significant(P<0.05). After two- week treatment, the incidence of adverse reactions was 10.34% in the treatment group and 27.59% in the control group,the difference being significant(P<0.05). Conclusion:Xiao'er Feike granules combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute children bronchiolitis can relieve clinical effects,improve respiratory inflammatory responses and the lung function,and shorten the course of the disease.

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周江颖,余跃帅,朱益锋.小儿肺咳颗粒联合氨溴特罗口服溶液治疗小儿急性支气管炎临床研究[J].新中医,2021,53(19):143-147

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  • 在线发布日期: 2021-10-09
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