基于真实世界分析喜炎平注射液治疗心肌损害及心肌炎的临床用药特征
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R542.2

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国家重点研发计划项目(2018YFC1707410)


Analysis on Clinical Medication Characteristics of Xiyanping Injection for Myocardial Damage and Myocarditis Based on Real World Study
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    摘要:

    目的:基于真实世界分析喜炎平注射液治疗心肌损害及心肌炎临床用药特征。方法:提取全国39 家大型三级甲等医院的医院信息系统(HIS) 心肌损害及心肌炎患者诊疗数据,分析了39 家医院的住院患者的HIS 数据库信息。采用SAS9.4 统计软件对患者的一般信息、用药信息及诊断信息进行统计分析,联合其他西药或中药的用药情况等采取SAS9.4 联合R 软件进行关联规则的构建及绘图的可视化表达。结果:20 894 例心肌损害与心肌炎患者中,男性多于女性,以6 岁以下儿童占比最多,临床使用的剂量疗程与药品说明书及指南基本相符合,喜炎平注射液治疗心肌损害与心肌炎最常见合并病为支气管肺炎(小叶性肺炎)、手足口病、上呼吸道感染等,最常用的用药方案为喜炎平注射液+氨溴索+布地奈德+磷肌酸。喜炎平注射液与第二代头孢菌素、干扰素类、抗生素类等抗感染药物联合使用较为常见。结论:本研究基于真实世界数据,揭示了真实世界中喜炎平注射液治疗心肌损害及心肌炎临床特征情况,在药品使用的安全性方面应注意药品联合使用的优势与劣势,为深入挖掘其适用疾病及促进喜炎平注射液在临床中的合理用药提供参考与借鉴。

    Abstract:

    Abstract:Objective:To analyze the clinical medication characteristics of Xiyanping injection for myocardial damage and myocarditis based on real world study. Methods:The diagnosis and treatment data of patients with myocardial damage and myocarditis were extracted from the Hospital Information Systerm(HIS) of 39 large grade A tertiary hospitals in China. The HIS database of inpatients in 39 hospitals was analyzed. General information,medication information and diagnosis information of patients were counted and analyzed by SAS9.4 statistical software. Based on medication situation of the other western medicine and Chinese medicine, the combination of SAS9.4 with R software was used to construct and draw association rules for visible expression. Results:Among 20 894 cases of patients with myocardial damage and myocarditis,there were more males than females,and the children under six years old accounted for the largest proportion. The dosage of clinical use and the course of treatment were basically in accordance with drug labeling and guidelines. When treating myocardial damage and myocarditis with Xiyanping injection,the most common complications included bronchopneumonia(lobular pneumonia), hand-foot-mouth disease and upper respiratory tract infection;the most commonly used medication regimen was Xiyanping injection and ambroxol and budesonide and phosphocreatine. Xiyanping injection was commonly used in combination with second-generation cephalosporins,interferons,antibiotics and other anti-infective drugs. Conclusion:Based on real world data,this study reveals the clinical characteristics of Xiyanping injection for myocardial damage and myocarditis based on real world study. In terms of medication safety, the attention should be paid to the advantages and disadvantages of the combined use of medicine,so as to provide reference for further exploring its applicable diseases and promoting the rational medication use of Xiyanping injection in clinical practice.

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张利丹,李利寻,王志飞,谢雁鸣,杨云云.基于真实世界分析喜炎平注射液治疗心肌损害及心肌炎的临床用药特征[J].新中医,2021,53(19):28-34

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  • 在线发布日期: 2021-10-09
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