Abstract：Objective：To discuss the administration rules of professor LIU Weisheng treating liver cancer based on data mining analysis. Methods： A total of 456 prescriptions of liver cancer were collected from Professor LIU Weisheng's outpatient clinic， and the database of those prescriptions was constructed. After data processing， frequency analysis and cluster analysis were carried out. Results：Chinese medicines that were commonly used for liver cancer by Professor LIU are Radix Bupleuri， Fructus Ligustri Lucidi， Radix Paeoniae Alba， Fructus Akebiae， Scorpio， and so on， mainly bitter- cold medicine. After the classification of top 30 Chinese medicine used frequently according to their main therapeutic effect， it could be summarized that the core treatment methods are smoothing the liver and strengthening the spleen， as well as removing blood stasis and inhibiting tumor. Based on the results of cluster analysis， a core prescription and four core combinations of Chinese medicine for liver cancer by Professor LIU could be concluded； the prescription is composed of Radix Bupleuri， Radix Paeoniae Alba， Radix et Rhizoma Glycyrrhizae， Fructus Ligustri Lucidi， Fructus Akebiae， Scorpio， Radix Codonopsis， Radix Astragali， and Poria. Conclusion： Professor LIU follows the idea of “disease differentiationsyndrome differentiation- symptom differentiation” throughout the process of diagnosis and treatment of liver cancer. In terms of disease differentiation， toxin- expelling and masses- dissipating medicine is used to inhibit the development of tumor. As for syndrome differentiation， medicine that can smooth the liver and regulate qi， strengthen the spleen and remove dampness， as well as invigorate blood and dissolve stasis is selected. Symptom- differentiation Chinese medicine which can drain dampness and remove jaundice，as well as strengthen the stomach and promote digestion can be added as a supplement.