缩泉胶囊、醒脾养儿颗粒联合艾灸治疗小儿遗尿症脾肾两虚证临床研究
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R256.54

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Clinical Study of Suoquan Capsules, Xingpi Yang'er Granules Combined with Moxibustion for Urinary Incontinence with Spleen-Kidney Deficiency Syndrome in Children
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    摘要:

    目的:观察缩泉胶囊、醒脾养儿颗粒联合艾灸治疗小儿遗尿症脾肾两虚证的临床疗效。方法:选择诊断为脾肾两虚证的小儿遗尿症患儿100 例为研究对象,按随机数字表法分为观察组50 例和对照组50 例,观察组予缩泉胶囊及醒脾养儿颗粒口服,穴位艾灸治疗。对照组予醋酸去氨加压素口服治疗。2 组治疗疗程均为3 个月。观察2 组临床总疗效、中医证候改善情况、膀胱容量、膀胱残余尿量、血精氨酸加压素、尿液渗透压、血红蛋白、血白蛋白、不良反应及复发率等指标。结果:治疗后,2 组脾肾两虚证积分均较治疗前降低,差异均有统计学意义(P<0.05);且观察组脾肾两虚证积分较对照组低,差异有统计学意义(P<0.05)。治疗后,2 组膀胱容量、血精氨酸加压素、尿液渗透压均较治疗前升高,差异均有统计学意义(P<0.05)。膀胱残余尿量较治疗前降低,差异有统计学意义(P<0.05)。治疗后,2 组膀胱容量、膀胱残余尿量、尿液渗透压、血精氨酸加压素分别比较,差异均无统计学意义(P>0.05)。治疗后,观察组治疗前后比较,血红蛋白及血白蛋白均明显上升,差异均有统计学意义(P<0.05)。对照组血红蛋白及血白蛋白治疗前后比较,差异均无统计学意义(P>0.05)。治疗后,观察组血红蛋白及血白蛋白分别均高于对照组,差异均有统计学意义(P<0.05)。总有效率观察组84.00%,对照组80.00%,2 组临床疗效总有效率比较,差异无统计学意义(P>0.05)。治疗结束后3 个月,2 组治疗总有效患儿复发率比较,观察组7.14%,对照组25.00%,差异有统计学意义(P<0.05)。观察组1 例出现轻微恶心症状,不良反应总发生率2.00%;对照组9 例出现轻微头痛、恶心、腹泻等症状,对症处理后症状消失,不良反应总发生率18.00%。2 组不良反应总发生率比较,差异有统计学意义(P<0.05)。结论:缩泉胶囊、醒脾养儿颗粒联合艾灸治疗小儿遗尿症具有效果好、复发率低、不良反应少、能改善体质等优点。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Suoquan capsules, Xingpi Yang'er granules combined with moxibustion for urinary incontinence with spleen- kidney deficiency syndrome in children. Methods:A total of 100 cases of children with urinary incontinence with spleen-kidney deficiency syndrome were selected as the study subjects and divided into the observation group and the control group according to the random number table method,50 cases in each group. The observation group was given the oral administration of Suoquan capsules and Xingpi Yang'er granules,and point moxibustion. The control group was given the oral administration of desmopressin acetate. Both groups were treated for three months. The total clinical efficacy,improvement of Chinese medicine syndrome,bladder volume,residual urine volume,blood arginine vasopressin,urine osmotic pressure,hemoglobin,albumin,adverse reactions and recurrence rate were observed in the two groups. Results: After treatment, scores of spleen- kidney deficiency syndrome in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05);the score in the observation group was lower than that in the control group, the difference being significant(P<0.05). After treatment, bladder volume, blood arginine vasopressin and urine osmotic pressure in the two groups were increased when compared with those before treatment, differences being significant(P<0.05), and residual urine volume was decreased when compared with that before treatment,the difference being significant(P<0.05). After treatment,when compared bladder volume,residual urine volume, urine osmotic pressure, and blood arginine vasopressin between the two groups, there was no significance in differences(P>0.05). After treatment,in the observation group,levels of hemoglobin and albumin were obviously increased when compared with those before treatment,differences being significant(P<0.05). In the observation group,there were no significant differences being found in the comparison of hemoglobin and albumin before treatment and those after treatment(P>0.05). After treatment,hemoglobin and albumin in the observation group were higher than those in the control group,differences being significant(P<0.05). The total effective rate was 84.00% in the observation group,and 80.00% in the control group,no significant difference being found in the comparison between the two groups(P>0.05). During the first three months after treatment,the recurrence rate of children with effective treatment was 7.14% in the observation group, and 25.00% in the control group, the difference being significant(P<0.05). There was one case of mild nausea in the observation group, and the total incidence of adverse reactions was 2.00% ; there were nine cases of mild headache, nausea, and diarrhea in the control group, and such symptoms disappeared after symptomatic treatments, the total incidence of adverse reactions being 18.00%. There was significance being found in the comparison of the total incidence of adverse reactions between the two groups(P<0.05). Conclusion: In the treatment of urinary incontinence in children, the therapy of Suoquan capsules,Xingpi Yang'er granules combined with moxibustion has the advantages of effectiveness,low recurrence rate,and less adverse reactions,and it can help improve physical fitness.

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吴杰,樊慧苏,林建军,吕建飞.缩泉胶囊、醒脾养儿颗粒联合艾灸治疗小儿遗尿症脾肾两虚证临床研究[J].新中医,2021,53(18):89-94

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  • 在线发布日期: 2021-09-24
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