Abstract： Objective： To observe the clinical effect of Suhuang Zhike capsules combined with tiotropium bromide for Chronic obstructive pulmonary disease(COPD) at stable stage. Methods： A total of 120 cases of COPD patients at stable stage were selected and divided into the control group and the observation group according to different treatment methods， 60 cases in each group. The control group was treated with tiotropium bromide，and the observation group was additionally treated with Suhuang Zhike capsules based on the treatment of the control group. Both groups were treated for three months. The lung function indexes，levels of inflammatory factors in serum，6-minute walking distance，and scores of St. George's Respiratory Questionnaire(SGRQ) were compared between the two groups. The clinical effect was compared between the two groups. Results：After treatment，forced expiratory volume in one second(FEV1)，forced vital capacity(FVC)，and FEV1/ FVC in the two groups were increased when compared with those before treatment(P＜0.05)，and the three indexes in the observation group were higher than those in the control group(P＜0.05). The total effective rate was 91.67% in the observation group，higher than that of 78.33% in the control group，the difference being significant(P＜0.05). After treatment，levels of high- sensitivity C- reactive protein(hs- CRP)， interleukin- 17(IL- 17)， and interleukin- 8(IL- 8) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of the three inflammatory factors above in the observation group were lower than those in the control group(P＜0.05). After treatment，6-minute walking distance in the two groups was increased when compared with that before treatment(P＜0.05)，and the SGRQ scores were decreased(P＜ 0.05)； 6- minute walking distance in the observation group was larger than that in the control group(P＜0.05)， and SGRQ score was lower(P＜0.05). Conclusion： In the treatment of COPD at stable stage， the therapy of Suhuang Zhike capsules combined with tiotropium bromide can enhance clinical effect，improve the lung function and quality of life，and reduce levels of inflammatory factors in serum.