Abstract：This paper is to explore the specific meaning of "mutual interference of the clear and the turbid"，the treatment methods and the influence on the later generations，in order to grasp the mechanism of this disease more comprehensively， and to flexibly adapt and use. In this paper，by selecting the relevant original text of Huangdi Neijing and combining with the ascending and descending of qi movement，the theory of "mutual interference of the clear and the turbid" is systematically sorted out and analyzed. Relevant literatures of exogenous febrile disease and epidemic febrile disease are inquired to excavate the application and development of the theory. In this paper，it is considered that "mutual interference of the clear and the turbid" leads to the disturbance of qi movement，which can be divided into two aspects：ascending and descending， exiting and entering. The treatment should be "adjusted according to different conditions"，that is，to raise the clear and direct the turbid downward， and diffuse the clear and disperse the turbid. Many syndromes and treatments of cold damage and warm disease revolve around this theory. The theory of "mutual interference of the clear and the turbid" is a significant pathogenesis，which is a further interpretation of the disturbance of qi movement，and has a far-reaching impact on the later generations.