Abstract： Objective： To observe the clinical effect of medicated bath with modified Yinchenhao tang for prevention and treatment of jaundice of newborns. Methods： A total of 110 cases of newborns with jaundice were divided into the control group and the observation group according to the random number table method，55 cases in each group. The control group was treated with blue light irradiation and routine nursing， and the observation group was additionally treated with medicated bath with modified Yinchenhao tang based on the treatment of the control group. Both groups were treated for five days. The clinical effect was compared between the two groups. The remission time of jaundice， the daily times of defecation， and the daily sleep time were recorded. Before and after treatment， levels of transcutaneous bilirubin(TCB)， serum total bilirubin(TBil) and serum direct bilirubin(DBil) were measured. Results：The total clinical effective rate was 94.55% in the observation group，higher than that of 80.00% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of TCB levels between the two groups(P＞ 0.05). After treatment for 1，2，3，4，and 5 days，levels of TCB were gradually decreased in the two groups(P＜0.05). After treatment for 2，3，4，and 5 days，TCB levels in the observation group were lower than those in the control group at the same time point(P＜0.05). Before treatment，there was no significant difference being found in the comparison of TBil and DBil levels between the two groups(P＞0.05). After treatment， levels of TBil and DBil in the two groups were decreased when compared with those before treatment(P＜0.05)，and the two levels in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the daily times of defecation and the daily sleep time between the two groups(P＞0.05). After treatment，the daily sleep time in the two groups was longer than that before treatment(P＜0.05)，and the daily sleep time in the observation group was longer than that in the control group(P＜0.05). The remission time of jaundice in the observation group was shorter than that in the control group，the difference being significant(P＜0.05). Conclusion：Based on blue light irradiation，medicated bath with modified Yinchenhao tang for newborns with jaundice can reduce their bilirubin， promote the remission of jaundice， shorten the course of disease，enhance the quality of sleep，and improve clinical effect.