Abstract： Objective： To observe the clinical effect of self- made Liqi Huoxue tang combined with routine western medicine for chronic pelvic inflammatory disease. Methods：A total of 100 cases of patients with chronic pelvic inflammatory disease were selected and divided into the observation group and the control group according to the random number table method，50 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally given self- made Liqi Huoxue tang based on the treatment of the control group.The clinical effect and the sizes of mass in the two groups were compared；the changes in hemorheology indexes and the levels of serum inflammatory factors before and after treatment in the two groups were observed. Results：After six weeks of treatment，the total clinical effective rate was 86.00% in the observation group，higher than that of 74.00% in the control group，the difference being significant(P<0.05). After six weeks of treatment，the levels of hematocrit，high shear viscosity of whole blood and low shear viscosity of whole blood in the two groups were decreased when compared with those before treatment， and the above levels in the observation group were lower than those in the control group(P＜0.05). After six weeks of treatment，the levels of interleukin-6，tumor necrosis factor-α and C-reactive protein in serum in the two groups were decreased when compared with those before treatment，and the above levels in the observation group were lower than those in the control group(P＜ 0.05). After six weeks of treatment， the average diameter of mass in the observation group was smaller than that in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of self-made Liqi Huoxue tang combined with routine western medicine has significant curative effect in treating chronic pelvic inflammatory disease， which can promote the reduction of the size of mass，accelerate blood circulation and reduce inflammatory reactions.