宣白承气汤治疗急性呼吸窘迫综合征临床研究
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R563.8

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浙江省临海市科技计划项目(2017YY10)


Clinical Study on Xuanbai Chengqi Tang for Acute Respiratory Distress Syndrome
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    摘要:

    目的:观察宣白承气汤治疗急性呼吸窘迫综合征(ARDS) 患者的疗效及对患者肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10) 水平的影响。方法:选取62 例ARDS 患者作为研究对象,按随机数字表法分为对照组和观察组各31 例。对照组给予基础治疗,观察组在对照组基础上给予宣白承气汤治疗。比较2 组临床疗效及治疗前后炎性因子、肺功能指标,记录2 组患者机械通气时间、重症监护室(ICU) 停留时间、住院时间。结果:观察组总有效率为93.55%,高于对照组67.74%,差异有统计学意义(P<0.05)。治疗前,2 组TNF-α、IL-1β、IL-10 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组TNF-α、IL-1β 水平较治疗前降低,观察组TNF-α、IL-1β 水平低于对照组(P<0.05);2 组IL-10 水平较治疗前升高,观察组IL-10 水平高于对照组(P<0.05)。治疗前,2 组肺功能指标比较,差异无统计学意义(P>0.05)。治疗后,2 组肺活量(VC)、第1 秒用力呼气容积(FEV1) /用力肺活量(FVC)、氧合指数(PaO2/FiO2) 较治疗前升高,观察组肺功能各项指标均高于对照组,差异均有统计学意义(P<0.05)。观察组机械通气时间、ICU 停留时间均低于对照组(P<0.05)。结论:宣白承气汤治疗ARDS 可提高临床疗效,降低TNF-α、IL-1β 水平,提高IL-10 水平,并改善患者肺功能。

    Abstract:

    Abstract: Objective: To observe the curative effect of Xuanbai Chengqi tang for acute respiratory distress syndrome (ARDS) and its effect on the levels of tumor necrosis factor- α(TNF- α),interleukin- 1β(IL- 1β) and interleukin- 10(IL- 10) in patients. Methods:A total of 62 cases of ARDS patients were selected and divided into the control group and the observation group according to the random number table method,31 cases in each group. The control group was given basic treatment and the observation group was additionally given Xuanbai Chengqi tang based on the treatment of the control group. The inflammatory factors and lung function indexes before and after treatment as well as the clinical effect in the two groups were compared. Duration of mechanical ventilation,intensive care unit(ICU) staying time and hospitalization time in the two groups were recorded. Results: The total effective rate was 93.55% in the observation group, higher than that of 67.74% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of TNF- α,IL-1β and IL-10 between the two groups(P>0.05). After treatment,the levels of TNF- α and IL- 1β in the two groups were decreased when compared with those before treatment, and the levels in the observation group were lower than those in the control group(P<0.05);the levels of IL-10 in the two groups were increased when compared with those before treatment,and the level in the observation group was higher than that in the control group (P<0.05). Before treatment, there was no significant difference being found in the comparison of lung function indexes between the two groups(P>0.05). After treatment, vital capacity(VC), forced expiratory volume in the first second(FEV1)/ forced expiratory vital capacity(FVC) and oxygenation indexes(PaO2/FiO2) in the two groups were increased when compared with those before treatment, and various indexes of lung function in the observation group were higher than those in the control group, differences being significant(P<0.05). Duration of mechanical ventilation and ICU staying time in the observation group were shorter than those in the control group(P<0.05). Conclusion: Xuanbai Chengqi tang for ARDS can improve the clinical effect and the lung function of patients,reduce the levels of TNF-α and IL-1β,and increase the level of IL-10.

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常盛.宣白承气汤治疗急性呼吸窘迫综合征临床研究[J].新中医,2021,53(17):55-58

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  • 在线发布日期: 2021-09-09
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