Abstract：Objective：To observe the curative effect of Angong Niuhuang pills combined with symptomatic treatment of western medicine on severe cerebral hemorrhage and its effect on cognitive function. Methods： A total of 90 cases of patients with severe cerebral hemorrhage were selected and divided into the treatment group and the control group according to the random number table method，45 cases in each group. The control group was treated with symptomatic treatment of western medicine，and the treatment group was additionally treated with Angong Niuhuang pills based on the treatment of the control group. After two weeks of continuous treatment， the clinical effect， Chinese medicine syndrome score， cognitive function and neurological impairment in the two groups were evaluated，and the levels of serum high-sensitivity C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) were measured. Results：The total effective rate was 93.33% in the treatment group，higher than that of 71.11% in the control group(P＜0.05). When compared with those in the same group after successful rescue， Chinese medicine syndrome score， scores of National Institutes of Health Stroke Scale (NIHSS)，as well as levels of hs-CRP and BNP in serum in the two groups were decreased after medication(P＜0.05)，and the scores of Mini- Mental State Examination(MMSE) were increased(P＜0.05). After medication， Chinese medicine syndrome score，NIHSS score，as well as levels of hs-CRP and BNP in serum in the treatment group were lower than those in the control group(P＜0.05)，and the MMSE score was higher(P＜0.05). Conclusion：The therapy of Angong Niuhuang pills combined with symptomatic treatment of western medicine has a significant curative effect on severe cerebral hemorrhage， which can effectively relieve clinical symptoms，improve cognitive function and neurological function，alleviate inflammatory responses，and reduce BNP level.