Abstract： Objective： To observe the curative effect of Wuling capsules for coronary heart disease complicated with depression of heart-kidney noninteraction type and its effect on the levels of noradrenaline(NE) and 5-hydroxytryptamine(5-HT) in serum. Methods： A total of 110 cases of patients with coronary heart disease complicated with depression were selected and divided into the control group and the observation group according to the random number table method， 55 cases in each group. Both groups were given routine treatment measures in modern medicine； the control group was given lorazepam tablets， and the observation group was additionally given Wuling capsules based on the treatment of the control group. Both groups were treated for eight weeks. Before and after treatment，the changes in the scores of Hamilton Depression Scale(HAMD- 17) and Symptom Check List(SCL- 90) as well as the levels of NE and 5- HT in serum in the two groups were compared. The clinical effect was compared between the two groups. Results： After eight weeks of treatment， the total effective rate was 94.55% in the observation group and 80.00% in the control group， the difference being significant(P＜0.05)； the scores of HAMD- 17 and SCL- 90 in the two groups were decreased when compared with those before treatment(P＜0.01)，and the above two scores in the observation group were lower than those in the control group(P＜0.01). The levels of NE and 5- HT in serum in the two groups were increased when compared with those before treatment(P＜0.01)， and the above two indexes in the observation group were higher than those in the control group(P＜ 0.01). Conclusion： Wuling capsules can improve the brain nerve signal transduction function， reduce the degree of depression and effectively relieve the clinical symptoms of coronary heart disease complicated with depression of heartkidney noninteraction type.