Abstract： Objective： To observe the clinical effect of mindfulness therapy combined with Anshen Yiqi Buxin tang for affective disorder after withdrawal of alcohol dependence. Methods：A total of 122 cases of patients with affective disorder after withdrawal of alcohol dependence were selected as the study objects， and divided into the control group and the observation group according to the random number table method， 61 cases in each group. The control group was given Anshen Yiqi Buxin tang，and the observation group was additionally given mindfulness therapy based on the treatment of the control group. The clinical effect， state of anxiety and depression， and quality of life were compared between the two groups. Results：The total effective rate was 96.72% in the observation group，significantly higher than that of 83.61% in the control group，the difference being significant(P＜0.05). Before treatment，when compared scores of Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA) between the two groups，there was no significance in the difference(P＞ 0.05). After treatment，scores of HAMD and HAMA in the two groups were decreased when compared with those before treatment， and the two scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the score of quality of life between the two groups(P＞0.05). After treatment，scores of mental health，life vitality，emotional role，social relation，general health，physiological function，physiological role，and body pain in the two groups were increased when compared with those before treatment(P＜0.05)，and each score in the observation group was higher than that in the control group(P＜0.05). Conclusion： In the treatment of affective disorder after withdrawal of alcohol dependence， the therapy of mindfulness therapy combined with Anshen Yiqi Buxin tang can effectively enhance clinical effect， improve quality of life， and relieve affective disorder after alcohol withdrawal.