Abstract：Objective：To observe the clinical effect of modified Guipi tang combined with five-element music therapy for insomnia of heart- spleen deficiency type during perimenopause period. Methods： A total of 82 cases of patients with insomnia of heart-spleen deficiency type during perimenopause period were selected and divided into the Guipi tang group， the music therapy group，and the combination group according to the random number table method. The Guipi tang group was given the oral administration of modified Guipi tang； the music therapy group was treated with five- element music therapy； the combination group was treated with modified Guipi tang combined with five- element music therapy. Clinical effect，scores of Pittsburgh Sleep Quality Index(PSQI)，and scores of Menopause Rating Scale(MRS) were compared among the three groups. Results：The total effective rate was 89.66% in the combination group，74.07% in the Guipi tang group， and 65.38% in the music therapy group. The total effective rate in the combination group was higher than those of the other two groups，the difference being significant(P＜0.05). Before treatment，when compared each score of PSQI and the total score among the three groups，there was no significance in the difference(P＞0.05). After treatment，each score of PSQI and the total score in the three groups were decreased when compared with those before treatment， and the scores in the combination group were lower than those in the other two groups， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of MRS scores among the three groups(P＞ 0.05). After treatment， MRS scores in the three groups were decreased when compared with those before treatment(P＜ 0.05)， and the score in the combination group was lower than that in the music therapy group(P＜0.05). Conclusion： The therapy of modified Guipi tang combined with five-element music therapy can significantly improve the insomnia symptom of patients of heart-spleen deficiency type during perimenopause period，and improve the Quality of life during perimenopause period.