加味苏子降气汤联合西药治疗慢性阻塞性肺疾病急性加重期临床研究
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Clinical Study on Modified Suzi Jiangqi Tang Combined with Western Medicine for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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    摘要:

    目的:观察加味苏子降气汤联合西药治疗慢性阻塞性肺疾病急性加重期(AECOPD) 的临床疗效。方法:将确诊为AECOPD 的86 例患者随机分为治疗组和对照组各43 例。2 组均给予西医常规治疗,治疗组联合加味苏子降气汤治疗。观察比较2 组临床疗效、肺功能指标和血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、缺氧诱导因子-1α(HIF-1α) 水平。结果:治疗后,2 组喘息、咳嗽和咳痰积分均较治疗前下降,差异有统计学意义(P<0.05);治疗组优于对照组,差异有统计学意义(P<0.05)。治疗组总有效率为95.3%,对照组为76.7%,差异有统计学意义(P<0.05)。2 组治疗后各项指标(肺功能、炎症指标) 均显著改善,治疗组更具优势,差异有统计学意义(P<0.05)。结论:加味苏子降气汤联合西药治疗AECOPD 临床疗效确切,较单纯使用西药能更好地缓解临床症状,提高临床疗效,改善肺功能,降低血清IL-6、IL-8、HIF-1α 水平,减轻炎症反应。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Suzi Jiangqi tang combined with western medicine for acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods:A total of 86 cases of patients diagnosed as AECOPD were randomly divided into the treatment group and the control group,43 cases in each group. Both groups were treated with routine western medicine,and the treatment group was additionally treated with modified Suzi Jiangqi tang. The clinical effect, the lung function indexes and the levels of interleukin- 6(IL- 6), interleukin- 8(IL- 8) and hypoxia- inducible factor- 1α(HIF- 1α) in serum in the two groups were observed and compared. Results: After treatment, the scores of wheezing,coughing and expectoration in the two groups were decreased when compared with those before treatment,the difference being significant(P<0.05); the scores in the treatment group were better than those in the control group, the difference being significant(P<0.05). The total effective rate was 95.3% in the treatment group and 76.7% in the control group, the difference being significant(P<0.05). After treatment, the indexes in the two groups were increased when compared with those before treatment,and the index in the treatment group was higher than that in the control group,the difference being significant(P<0.05). Conclusion:The therapy of modified Suzi Jiangqi tang combined with western medicine for AECOPD has definite clinical effect. When compared with the simple use of western medicine, it can better alleviate clinical symptoms,improve the clinical effect and lung function,and reduce the levels of IL-6,IL-8 and HIF-1α in serum and inflammatory reactions.

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蒋丽霞,蒋文蔚.加味苏子降气汤联合西药治疗慢性阻塞性肺疾病急性加重期临床研究[J].新中医,2021,53(16):9-12

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  • 在线发布日期: 2021-08-23
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