Abstract：This paper introduces the experience of Prof. WANG Kungen in treating chloasma from the five- zang organs based on syndrome differentiation. Prof. WANG believes that the pathogenesis of chloasma is dysfunction of the five- zang organs， leading to abnormal qi movement and blood， under- nourishment of facial skin and over time resulting in pigmentation. It is advocated to treat the disease from the five-zang organs based on syndrome differentiation：to treat from the liver：balance yin and yang，and treat qi and blood together；to treat from the spleen：strengthen the spleen and tonify qi，nourish blood and beautify the face；to treat from the kidney：essence and blood are from the same source，so it is to nourish the kidney and supplement essence；to treat from the lung：regulate qi movement，and treat the exterior disease from the interior；to treat from the heart：rest the heart and calm the mind，and nourish and invigorate the blood. The course of the disease is long，and it is easy to have repeated attacks. For one thing，when prescribing and medicating，the main syndromes should be given priority and the other syndromes should be taken into account. For another thing，the disease has a great influence on the patient's mental and emotional state，so soothing the liver and regulating qi should run through the whole process. The overall treatment is as follows：to treat the five-zang organs，treat qi and blood together，regulate qi as the priority，take blood as the basis，nourish the face and eliminate spots.