Abstract： Objective： To discuss the effect of integrated Chinese and western medicine nursing on syndrome improvement and prognosis of helicobacter pylori(Hp) -related peptic ulcer. Methods：A total of 82 cases of patients with Hprelated peptic ulcer were selected as the study subjects and divided into the study group and the control group according to odd-even number method，41 cases in each group. The control group was given routine nursing，and the study group was given integrated Chinese and western medicine nursing. After four- week nursing， Chinese medicine syndrome score， quality of life， and nursing satisfaction were observed and compared before and after nursing between the two groups. Results：After nursing，total Chinese medicine syndrome scores in the two groups were decreased，and the score in the study group was lower than that in the control group(P＜0.05). The score of quality of life in the study group was significantly higher than that in the control group(P＜0.05). Satisfaction in the study group was higher than that in the control group(P＜ 0.05). Conclusion：For patients with Hp-related peptic ulcer，integrated Chinese and western medicine nursing can achieve a satisfying nursing effect，promote the improvement of Chinese medicine syndrome.