Abstract： Objective： To observe the clinical effect of Huoxue Huayu Yiqi tang combined with Chinese medicine characteristic comprehensive nursing for patients with acute myocardail infarction undergoing percutaneous coronary intervention. Methods： A total of 160 cases of patients with acute myocardial infarction undergoing percutaneous coronary intervention were randomly divided into the control group and the observation group， 80 cases in each group. The control group was given routine nursing，and the observation group was treated with Huoxue Huayu Yiqi tang combined with Chinese medicine characteristic comprehensive nursing. Clinical effect， nursing satisfaction， Barthel indexes，Self-rating Anxiety Scale(SAS) scores ， Self-rating Depression scale(SDS) scores，the length of hospital stay and the incidence of complications in the two groups were recorded，compared and analyzed. Results：The total effective rate， the nursing satisfaction and the incidence of complications were 92.50%，93.75% and 3.75% respectively in the observation group and 81.25% ， 82.50% and 12.50% respectively in the control group， differences being significant(P＜0.05). After treatment， the length of hospital stay in the observation group was shorter than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of SAS and SDS between the two groups(P＞0.05). After treatment，the scores of SAS and SDS in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above two scores in the observation group were lower than those in the control group(P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of Barthel indexes between the two groups(P＞0.05). After treatment，Barthel indexes in the two groups were increased when compared with those before treatment(P＜0.05)， and Barthel index in the observation group was higher than that in the control group(P＜0.05). Conclusion：The therapy of Huoxue Huayu Yiqi tang combined with Chinese medicine characteristic comprehensive nursing for patients with acute myocardail infarction undergoing percutaneous coronary intervention can enhance the clinical effect， speed up the recovery rate，reduce the complications，and improve their satisfaction with medical staff.