Abstract：Objective：To observe and compare the application effect of acupuncture combined with local anesthesia with that of local anesthesia combined with analgesic medicine on percutaneous vertebroplasty(PVP). Methods ： A total of 120 cases of patients with osteoporotic vertebral compression fractures who underwent PVP were selected and randomly divided into the observation group and the control group， 60 cases in each group. The control group was given local anesthesia combined with analgesic medicine， and the observation group was given acupuncture combined with local anesthesia. Before surgery(t1)， during puncture(t2)， during bone cement perfusion(t3)， and at the end of surgery(t4)， the score of Visual Analogue Scale(VAS) of pain， Ramsay sedation score， blood pressure， and heart rate were compared between the two groups. The dosage of analgesic medicine，duration of anesthesia，and duration of surgery were compared between the two groups. Results：At t1，there was no significant difference being found in the comparison of the score of VAS between the two groups(P＞0.05)；from t2 to t4，the score in the observation group was lower than that in the control group(P＜0.05). From t1 to t4， when compared Ramsay score， systolic pressure， diastolic pressure， and heart pressure between the two groups，there was no significance in differences(P＞0.05). The dosage of analgesic medicine was less than that in the control group(P＜0.05)，and duration of anesthesia was longer(P＜0.05). There was no significant difference being found in the comparison of the duration of surgery between the two groups(P＞0.05). Conclusion： The application of acupuncture combined with local anesthesia to PVP has a better analgesic effect than local anesthesia combined with analgesic medicine，with a smaller dosage of analgesic medicine. Acupuncture combined with local anesthesia has a similar effect to analgesic medicine in terms of maintenance of stability of vital signs，but duration of anesthesia is prolonged.