温经蠲痹汤联合西药治疗类风湿性关节炎寒湿痹阻证的疗效及对氧化应激的调节作用
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R593.22

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Curative Effect of Wenjing Juanbi Tang Combined with Western Medicine for Rheuma⁃ toid Arthritis with Cold- Dampness Obstruction Syndrome and Its Regulating Effect on Oxidative Stress
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    摘要:

    目的:观察温经蠲痹法联合西药治疗类风湿性关节炎(RA) 寒湿痹阻证的疗效以及对血清超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、丙二醛(MDA) 水平的调节作用。方法:选取120 例寒湿痹阻型RA 患者,按随机数字表法分为观察组和对照组各60 例。对照组给予甲氨蝶呤加小剂量醋酸泼尼松片,观察组给予温经蠲痹汤联合甲氨蝶呤加小剂量醋酸泼尼松。2 组疗程均为3 个月。比较2 组的临床疗效,观察2 组治疗前后血沉(ESR)、类风湿因子(RF)、C-反应蛋白(CRP)、抗环瓜氨酸肽(CCP) 水平以及氧化应激指标[超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、丙二醛(MDA)]水平及寒湿痹阻证症状评分的变化。结果:治疗后,观察组总有效率为85.00%,高于对照组的69.49%,差异有统计学意义(P<0.05)。2 组ESR、RF、CRP、CCP 水平均较治疗前降低(P<0.01),观察组4 项指标值均低于对照组(P<0.01)。2 组关节冷痛、肢冷、晨僵、关节屈伸不利、畏寒评分均较治疗前减少(P<0.01),观察组5 项症状评分均低于对照组(P<0.01)。2 组血清SOD、TAC 水平均较治疗前升高,MDA 水平均较治疗前下降,差异均有统计学意义(P<0.01);观察组血清SOD、TAC水平均高于对照组,MDA 水平则低于对照组,差异均有统计学意义(P<0.01)。结论:温经蠲痹汤联合西药治疗寒湿痹阻型RA可缓解临床症状,改善氧化应激状态,提高临床疗效。

    Abstract:

    Abstract: Objective: To observe the curative effect of Wenjing Juanbi tang combined with western medicine for rheumatoid arthritis(RA) with cold- dampness obstruction syndrome and its regulating effect on the levels of superoxide dismutase(SOD), total antioxidant capacity(TAC) and malonaldehyde(MDA) in serum. Methods: A total of 120 cases of RA patients with cold- dampness obstruction syndrome were selected and divided into the observation group and the control group according to the random number table method,60 cases in each group. The control group was given methotrexate and low- dose prednisone acetate tablets,and the observation group was additionally given Wenjing Juanbi tang based on the treatment of the control group. Both groups were treated for three months. The clinical effect in the two groups was compared; the changes in the levels of erythrocyte sedimentation rate(ESR), rheumatoid factor(RF), C- reactive protein (CRP), anti- cyclic citrullinated peptide(CCP), and oxidative stress indexes including Superoxide dismutase(SOD), total antioxidant capacity(TAC) and Malonaldehyde(MDA) as well as the symptom scores of cold-dampness obstruction syndrome before and after treatment in the two groups were observed. Results: After treatment, the total effective rate was 85.00% in the observation group,higher than that of 69.49% in the control group,the difference being significant(P< 0.05). The levels of ESR, RF, CRP and CCP in the two groups were decreased when compared with those before treatment(P<0.01),and the above four indexes in the observation group were lower than those in the control group(P<0.01). The scores of cold pain in joints,cold limbs,morning stiffness,unfavorable flexion and extension of joints and fear of cold in the two groups were decreased when compared with those before treatment(P<0.01), and the scores of the above five items in the observation group were lower than those in the control group(P<0.01). The levels of SOD and TAC in serum in the two groups were increased when compared with those before treatment,and MDA levels were decreased,differences being significant(P<0.01);the levels of SOD and TAC in serum in the observation group were higher than those in the control group,and the level of MDA was lower,differences being significant(P<0.01). Conclusion:The therapy of Wenjing Juanbi tang combined with western medicine for RA of cold- dampness obstruction type can alleviate the clinical symptoms, improve the oxidative stress state,and enhance the clinical effect.

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张燕萍.温经蠲痹汤联合西药治疗类风湿性关节炎寒湿痹阻证的疗效及对氧化应激的调节作用[J].新中医,2021,53(15):91-95

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  • 在线发布日期: 2021-08-10
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