Abstract：Objective：To study the effect of Ma's Bushen Zhuyun therapy combined with dehydroepiandrosterone(DHEA) on fertility of elderly patients with infertility due to diminished ovarian reserve(DOR) of the kidney yang deficiency type. Methods：Patients with infertility due to DOR of the kidney yang deficiency type were randomly divided into two groups. Both groups were treated with oral administration of DHEA capsule，and the Chinese medicine group was additionally treated with Ma's Bushen Zhuyun therapy. Both groups were treated for three menstrual periods. Before treatment and after the treatment of three menstrual periods，changes in Chinese medicine syndrome scores，indexes of ovarian hormones ［anti-mullerian hormone(AMH)， follicle- stimulating hormones(FSH)， luteinizing hormone(LH)］， and ovarian ultrasound parameters［antral follicle count(AFC)，mean peak systolic velocity(mPSV) of bilateral ovarian interstitial artery，mean resistive index(mRI)］were observed in the two groups. Results： After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.01)，and the score in the Chinese medicine group was lower than that in the DHEA group(P＜0.01). Levels of AMH in the two groups were increased when compared with those before treatment(P＜0.01)；levels of FSH and FSH/LH in the Chinese medicine group were decreased when compared with those before treatment(P＜0.01). The level of AMH in the Chinese medicine group was higher than that in the DHEA group(P＜ 0.01)， and levels of FSH and FSH/LH were lower than those in the DHEA group(P＜0.01). AFC in the two groups was increased when compared with that before treatment(P＜0.01)， and AFC and mPSV value in the Chinese medicine group were larger than those in the DHEA group， differences being significant(P＜0.01). Conclusion： In the treatment of elderly patients with infertility due to DOR of the kidney yang deficiency type，the therapy of Ma's Bushen Zhuyun therapy combined with DHEA can effectively slow down the rapid depletion of retained primordial follicles in ovary， and improve ovarian reserve，thus，it can be expected to enhance the pregnancy probability.