Abstract：Objective：To observe the clinical effect of Tonglin Lishi Yiqi prescription combined with acupuncture for renal calculi. Methods：A total of 130 cases of patients with renal calculi were selected and divided into the control group and the observation group according to the random number table method， 65 cases in each group. The control group was given routine western medicine， and the observation group was additionally given Tonglin Lishi Yiqi prescription combined with acupuncture based on the treatment of the control group. The clinical effect was compared between the two groups. Before and after treatment， Chinese medicine syndrome score， the kidney function index， and quality of life were compared between the two groups. Results：The total effective rate was 96.92% in the observation group，higher than that of 78.46% in the control group， the difference being significant(P＜0.05). Before treatment， when compared Chinese medicine syndrome scores including lumbar pain and abdominal pain， interruption of urination， difficult painful urination， reddish yellow urine，dark red tongue with yellow and slimy fur between the two groups，there was no significance in the difference (P＞0.05). After treatment， Chinese medicine syndrome scores including lumbar pain and abdominal pain， interruption of urination，difficult painful urination，reddish yellow urine，dark red tongue with yellow and slimy fur in the two groups were decreased when compared with those before treatment(P＜0.05)，and the Chinese medicine syndrome scores above in the observation group were lower than those in the control group(P ＜ 0.05). Before treatment ， when compared levels of β 2-microglobulin(β2-MG)，cystatin C(CysC)，blood urea nitrogen(BUN)，and creatinine(Cr) between the two groups，there was no significance in the difference(P＞0.05). After treatment，levels of β2- MG，CysC，BUN，and Cr in the two groups were decreased when compared with those before treatment(P＜0.05)， and the four levels in the observation group were lower than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of each score of quality of life between the two groups(P＞0.05). After treatment，each score of quality of life in the two groups was increased when compared with that before treatment(P＜0.05)，and each score above in the observation group was higher than that in the control group(P＜0.05). Conclusion：The therapy of Tonglin Lishi Yiqi prescription combined with acupuncture has a significant curative effect in the treatment of renal calculi， which can significantly improve clinical symptoms，the kidney function，and quality of life.