Abstract：Objective：To observe the clinical effect of Renshen Guipi tang combined with body acupuncture for insomnia with heart-spleen deficiency syndrome. Methods：A total of 78 cases of patients with insomnia were divided into the control group and the observation group according to the random number table method，39 cases in each group. The control group was given estazolam tablets，and the observation group was treated with oral administration of Renshen Guipi tang combined with body acupuncture. Both groups were treated for four weeks. The scores of Pittsburgh Sleep Quality Index(PSQI)，the clinical effect and the polysomnography monitoring in the two groups were compared. Results：After treatment，the PSQI scores in the two groups were decreased(P＜0.01)； the decrease of PSQI score in the observation group was more significant when compared with that in the control group(P＜0.01). The total effective rate in the observation group was higher than that in the control group(P＜0.05). After treatment，the total sleep time in the two groups was significantly increased， and the sleep latency and the number of wakefulness were decreased(P＜0.01)；the increase of the total sleep time in the observation group was more significant when compared with that in the control group，and the decreases of the sleep latency and the number of wakefulness were more significant(P＜0.01). Conclusion： Renshen Guipi tang combined with body acupuncture can significantly improve the clinical symptoms and clinical effect of patients with insomnia with heart- spleen deficiency syndrome.