Abstract： Objective： To observe the clinical effect of Bufei Wenshen Huoxue prescription for chronic obstructive pulmonary disease(COPD) at stable stage and discuss its mechanism. Methods：A total of 120 cases of patients with COPD at stable stage were selected，and divided into the observation group and the control group according to the random number table method， 57 and 63 cases in each group respectively. The control group was given salmeterol fluticasone， and the observation group was additionally given Bufei Wenshen Huoxue prescription based on the treatment of the control group. Both groups were treated for three months. Before and after treatment， forced expiratory volume in one second(FEV1)， forced vital capacity(FVC)， and the ratio of FEV1 to FVC(FEV1/FVC) were compared between the two groups. Before and after treatment， the levels of interleukin- 1(IL- 1)， interleukin- 8(IL- 8)， tumor necrosis factor- α(TNF- α)， superoxide dismutase(SOD)，lipid peroxide(LPO)，and glutathione peroxidase(GSH-Px) were compared between the two groups. Before and after treatment， Chinese medicine syndrome scores， the score of St.George's Respiratory Questionnaire(SGRQ) for evaluating quality of life，as well as levels of matrix metalloproteinase- 9(MMP- 9) and tissue inhibitor of metalloproteases- 1 (TIMP- 1) were compared between the two groups. Results： After treatment， the total effective rate was 89.5% in the observation group，higher than that of 73.0% in the control group. When compared with those before treatment in the same group，levels of FEV1，FVC，FEV1/FVC，GSH- Px，and SOD in the two groups were increased after treatment(P＜0.05)； Chinese medicine syndrome scores of cough， expectoration， and gasping， levels of IL- 1， IL- 8， TNF- α， MMP- 9， TIMP- 1，MMP-9/TIMP- 1，and LPO，as well as each score of SGRQ and the total score were decreased(P＜0.05). After treatment，levels of FEV1，FVC，FEV1/FVC，GSH- Px，and SOD in the observation group were higher than those in the control group(P＜0.05)；Chinese medicine syndrome scores of cough，expectoration，and gasping，levels of IL-1，IL-8， TNF- α， MMP- 9， TIMP- 1， and LPO， as well as each score of SGRQ and the total score were lower(P＜0.05). During treatment，there was no severe adverse reaction in the two groups. Conclusion：Bufei Wenshen Huoxue prescription can relieve inflammatory responses of patients with COPD at stable stage， reduce oxidative stress reactions， inhibit airway remodeling，and regulate protease imbalance. It has a significant clinical effect with safety and reliability.