Abstract：Objective：To observe the effect of Shengmai yin combined with sacubitril valsartan sodium tablets on levels of N- terminal B- type natriuretic peptide(NT- proBNP)， soluble intercelluar adhesion molecule- 1(sICAM- 1)， and plasma brain natriuretic peptide(BNP) in patients with chronic heart failure. Methods：A total of 80 cases of patients with chronic heart failure were selected and divided into the control group and the observation group according to the random number table method，40 cases in each group. The control group was given oral administration of sacubitril valsartan sodium tablets，and the observation group was additionally given oral administration of Shengmai yin based on the treatment of the control group. The clinical effect and improvement of clinical symptoms were compared between the two groups. The change in the heart function before and after treatment and levels of NT- proBNP， sICAM- 1， and BNP were analyzed. Results： The total effective rate was 97.50% in the observation group and 77.50% in the control group， the difference being significant(P＜ 0.05). The disappearance time of lack of strength， lower extremity edema， and dyspnea in the observation group was significantly earlier than that in the control group，and 6-minute walking distance was significantly longer，differences being significant(P＜0.05). Before treatment， when compared left ventricle ejection fraction(LVEF)， left ventricular end- diastolic diameter(LVEDD)，and left ventricular end-systolic diameter(LVESD) between the two groups，there was no significance in the difference(P＞0.05). After treatment，LVEF levels in the two groups were increased when compared with those before treatment， and LVEDD and LVESD were decreased(P＜0.05). After treatment， LVEF in the observation group was higher than that in the control group， and LVEDD and LVESD were lower(P＜0.05). Before treatment， when compared levels of NT- proBNP， sICAM- 1， and BNP between the two groups， there was no significance in the difference(P＞0.05). After treatment，levels of NT-proBNP，sICAM-1，and BNP in the two groups were decreased when compared with those before treatment(P＜0.05)， and the three levels in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Shengmai yin combined with sacubitril valsartan sodium tablets has a significant curative effect in the treatment of chronic heart failure. It can significantly improve clinical symptoms and the heart function，and reduce levels of NT-proBNP，sICAM-1，and BNP.