Abstract：Objective：To observe the curative effect of Yinchen tang and modified Ganlu Xiaodu pills on chronic hepatitis B with syndrome of dampness-heat amassing and steaming and its effect on intestinal flora. Methods：A total of 82 cases of patients with chronic hepatitis B with syndrome of dampness-heat amassing and steaming were enrolled as the study objects， and divided into the control group and the observation group according to the random number table method ， 41 cases in each group. The control group was given entecavir tablets， and the observation group was additionally given Yinchen tang and modified Ganlu Xiaodu pills based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effect was compared between the two groups. Before and after treatment， changes in the lung function，the main symptom scores of syndrome of dampness- heat amassing and steaming，and levels of intestinal flora were observed in the two groups. Results： After twelve- week treatment， the total effective rate was 95.12% in the observation group， and 75.61% in the control group， the difference being significant(P＜0.05). Levels of Aspartate aminotransferase(AST)， Alanine aminotransferase(ALT)， and γ- glutamyl transpeptidase(GGT) in the two groups were decreased when compared with those before treatment(P＜0.01)，and the three levels above in the observation group were lower than those in the control group(P＜0.01). Scores of yellow skin and eye，reddish yellow urine，dry mouth and bitter taste in the mouth in the two groups were decreased when compared with those before treatment(P＜0.01)，and the three symptom scores in the observation group were lower than those in the control group(P＜0.01). The copy number of bifidobacterium and lactobacillus in the two groups was increased when compared with that before treatment， and copy number of escherichia coli and enterococcus were decreased(P＜0.01)；the improvement of bifidobacterium，lactobacillus， escherichia coli，and enterococcus in the observation group was better than that in the control group(P＜0.01). Conclusion： In the treatment of chronic hepatitis B with syndrome of dampness- heat amassing and steaming， the therapy of Yinchen tang and modified Ganlu Xiaodu pills has a significant curative effect. It can effectively reduce Chinese medicine syndrome scores，regulate the number of intestinal flora，and improve the lung function.