中药复方治疗多囊卵巢综合征高雄激素血症用药规律研究
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R271.9

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Study on Administration Rule of Chinese Herbal Compound in Treating Hyperandro⁃ genemia in Polycystic Ovary Syndrome
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    摘要:

    目的:探讨中药复方治疗多囊卵巢综合征(PCOS) 患者高雄激素血症的用药规律。方法:检索中国期刊全文数据库(CNKI)、万方医学网数据库和维普期刊数据库三大数据库自建库至2019 年9 月19 日公开发表的学术论文,筛选相关文献,整理文献中使用的中药复方,建立数据库,统计分析中药复方中的中药分类、性味归经,并对频数≥5 的中药采用因子分析法和关联规则分析法进一步挖掘用药规律。结果:共纳入46 篇文献,46 首方剂,99 味中药,14 类药物。使用频率前三位的中药类别依次是补虚药、清热药、活血化瘀药;药性以温为主,寒次之;主要药味为甘、辛、苦;主要归经为肝经,其次为肾经、脾经。用药频数≥5 的31 味中药,共提取出10 个公因子,获得19 对关联性高的药对组合。结论:中药复方治疗PCOS 患者高雄激素血症多将补虚药与清热药联合使用。

    Abstract:

    Abstract: Objective: To investigate the administration rule of Chinese herbal compound in the treatment of hyperandrogenemia in patients with polycystic ovary syndrome(PCOS). Methods: The academic papers published from the database establishment day to September 19, 2019 were searched from China National Knowledge Infrastructure(CNKI), Wanfang Medical Network Database and VIP Journal Database. After selecting relevant literatures and sorting out the Chinese herbal compound adopted in them,a database was established to statistically analyze the categories,natures,flavors and meridians of Chinese herbs in the Chinese herbal compound. What's more,factor analysis and association rule analysis were used to further explore the administration rule by analyzing the Chinese herbs whose frequency was five or more than five. Results:A total of 46 literatures,46 prescriptions,99 Chinese herbs and 14 kinds of medicine were included. The top three categories of Chinese herbs in frequency of use were,in turn,herbs for supplementing deficiency,herbs for clearing heat and herbs for invigorating blood and dissolving stasis. The main natures of the herbs were warm,followed by cold. The main flavors were sweet, spicy and bitter. The main meridians were liver meridian, followed by kidney meridian and spleen meridian. A total of 10 common factors were extracted from 31 Chinese herbs with a frequency of five or more than five,and 19 pairs of highly correlated combinations were obtained. Conclusion: In the treatment of hyperandrogenemia in PCOS patients,the combination of herbs for supplementing deficiency and herbs for clearing heat is usually used.

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程冉,朱宇航,曲凡.中药复方治疗多囊卵巢综合征高雄激素血症用药规律研究[J].新中医,2021,53(15):7-11

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  • 在线发布日期: 2021-08-10
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