Abstract： Objective： To observe the clinical effect of Longxuejie capsules combined with sulfadiazine silver cream for neonatal pressure ulcers. Methods：A total of 64 cases of neonates with pressure ulcers at stage II to III were divided into the control group and the observation group according to the random number table method，32 cases in each group. The control group was treated with sulfadiazine silver cream，and the observation group was additionally given external application with Longxuejie capsules based on the treatment of the control group. The clinical effect，wound healing time and incidences of adverse reactions in the two groups were compared. Results：The total effective rates of pressure ulcers at stageⅡandⅢ were 100% and 95.45% respectively in the observation group，and 78.95% and 71.43% respectively in the control group， the difference being significant(P＜0.05). The wound healing time of pressure ulcers at stageⅡandⅢin the observation group was shorter than that in the control group，the difference being significant(P＜0.05). During treatment，no severe adverse reaction occurred in the two groups. Conclusion：The therapy of Longxuejie capsules combined with sulfadiazine silver cream for neonatal pressure ulcers at stageⅡtoⅢhas definite curative effect，and can significantly accelerate the speed of wound healing without obvious adverse reaction.