Abstract：Objective：To observe the clinical effect of Tiaodu Anshen needling method combined with Chinese medicine prescription on patients with insomnia during perimenopausal period. Methods：A total of 96 cases of patients with insomnia during perimenopausal period were selected and divided into the control group and the observation group according to the random number table method，48 cases in each group. The control group was given Zishen Jieyu Anshen prescription，and the observation group was additionally treated with Tiaodu Anshen needling method based on the treatment of the control group. Before and after treatment， sleep quality， clinical symptoms， score of quality of life， and levels of sex hormones were compared between the two groups. The recurrence rate of insomnia was compared between the two groups. Results： When compared with those before treatment in the same group， scores of Pittsburgh Sleep Quality Index(PSQI)， Kupperman，and scale of Menopause-Specific Quality of Life(MENQOL)，as well as levels of follicle-stimulating hormones (FSH) and luteinizing hormone(LH) in the two groups were decreased after treatment(P＜0.05)， and levels of estradiol(E2) were increased(P＜0.05). After treatment，when compared with those in the control group，scores of PSQI，Kupperman and MENQOL，as well as levels of FSH and LH in the observation group were lower(P＜0.05)，and level of E2 was higher(P＜ 0.05). The recurrence rate was 12.50% in the observation group and 31.25% in the control group， the difference being significant(P＜0.05). Conclusion： In the treatment of patients with insomnia during perimenopausal period， the therapy of Tiaodu Anshen needling method combined with Chinese medicine prescription conduces to improving their sleep quality， symptoms of perimenopausal syndrome， levels of sex hormones， and quality of life， and reducing recurrence rate of insomnia.