Abstract：Objective：To observe the clinical effect of modified Tingli Dazao Xiefei tang combined with routine western treatment for heart failure. Methods：A total of 150 cases of patients with heart failure were randomly divided into the study group and the control group，75 cases in each group. The control group was given routine western treatment，and the study group was additionally treated with modified Tingli Dazao Xiefei tang based on the treatment of the control group. After treatment for four weeks，the clinical effect in the two groups was compared. The changes in Chinese medicine syndrome scores and blood gas analysis in the two groups before and after treatment were compared. Results：The total effective rate was 96.0% in the study group and 77.3% in the control group，the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the Chinese medicine syndrome scores including palpitations， fatigue， shortness of breath and breast pain between the two groups(P＞0.05)； after treatment， the above scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores in the study group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of oxygen saturation(SaO2)， partial pressure of oxygen(PO2)， partial pressure of carbon dioxide(PCO2) between the two groups(P＞0.05)；after treatment，SaO2 and PO2 in the two groups were increased when compared with those before treatment(P＜0.05)，and PCO2 levels were decreased(P＜0.05)，and the improvement in the study group was more significant than that in the control group(P＜0.05). Conclusion：Modified Tingli Dazao Xiefei tang combined with routine treatment for heart failure can improve clinical effect，clinical symptoms and blood gas analysis.