Abstract： Objective： To observe the curative effect of the therapy of Keyin tang combined with capotriol ointment on psoriasis and its effect on the levels of serum complement C3 and Nesfatin-1. Methods：A total of 150 patients with psoriasis were selected and divided into the observation group and the control group according to random number table method ， 75 cases in each group. The control group was treated with capotriol ointment，and the observation group was additionally treated with Keyin tang based on the treatment of the control group. Both groups were treated for six weeks. The clinical effect in the two groups was compared. The changes of skin lesions area，Psoriasis Area and Severity Index(PASI)，water content in the cuticle，transepidermal water loss，and levels of serum complement C3 and Nesfatin-1 were observed before and after treatment in the two groups. Results：After treatment，the area of skin lesions in both groups was reduced when compared with that before treatment respectively(P＜0.05)，and PASI was decreased respectively(P＜0.05). The area of skin lesions in observation group was smaller than that in the control group(P＜0.05)，and the PASI in the observation group was lower(P＜0.05). The markedly effective rate was 77.33% in the observation group，higher than that of 58.66% in the control group(P＜0.05). After treatment， the water content in the cuticle in both groups was increased when compared with that before treatment respectively(P＜0.05)， and transepidermal water loss was decreased respectively(P＜0.05). The water content in the cuticle in the observation group was larger than that in the control group，and transepidermal water loss was smaller(P＜0.05). After treatment， levels of serum complement C3 and Nesfatin- 1 in both groups were increased when compared with those before treatment(P＜0.05)，and the increase in the observation group was more significant than that in the control group(P＜0.05). Conclusion： The therapy of Keyin tang combined with capotriol ointment in the treatment of psoriasis can improve the clinical effect， reduce the skin lesion area， enhance the skin barrier function， and increase the levels of serum complement C3 and Nesfamin-1.