Abstract：Objective：To observe the effect of modified Huoxue Tuihuang tang on clinical symptoms，liver function and inflammatory factors of infants with cholestatic liver disease. Methods： A total of 94 cases of infants with cholestatic liver disease were divided into the control group and the observation group according to the random number table method ， 47 cases in each group. The control group was treated with routine western medicine， and the observation group was additionally treated with modified Huoxue Tuihuang tang based on the treatment of the control group. The clinical effect and the incidences of adverse reactions in the two groups were compared. Before and after treatment， Chinese medicine syndrome scores in the two groups were counted；liver function indexes including total bile acid(TBA)，direct bilirubin(DBil) and total bilirubin(TBil) as well as the levels of inflammatory factors including interleukin- 6(IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were detected；the sizes of liver and spleen in the two groups were compared. Results：The total effective rate was 91.49% in the observation group，higher than that of 76.60% in the control group，the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P＞0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the score in the observation group was lower than that in the control group， the difference being significant(P＜0.05). Before treatment， there were no significant difference being found in the comparison of the levels of TBA，DBil，TBil，IL-6 and TNF-α between the two groups(P＞0.05). After treatment，the levels of TBA，DBil，TBil，IL- 6 and TNF- α in the two groups were decreased when compared with those before treatment，and the levels of DBil，TBil，IL-6 and TNF-α in the observation group were lower than those in the control group， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the sizes of liver and spleen between the two groups(P＞0.05). After treatment， the sizes of liver and spleen in the two groups were reduced when compared with those before treatment，and the sizes in the observation group were smaller than those in the control group，differences being significant(P＜0.05). The incidence of adverse reactions was 4.26% in the observation group and 2.13% in the control group，there being no significant difference between the two groups (χ2=0.344， P=0.557). Conclusion： The therapy of modified Huoxue Tuihuang tang for infants with cholestatic liver disease can alleviate their clinical symptoms，improve the liver function and reduce the inflammatory response.