Abstract： Objective： To observe the clinical effect of modified Huagai powder combined with oseltamivir for children with influenza viral pneumonia with wind- cold obstructing lung syndrome. Methods： A total of 200 cases of children with influenza viral pneumonia with wind-cold obstructing lung syndrome were selected and divided into the observation group and the control group according to the random number table method， 100 cases in each group. The control group was given phosphate oseltamivir granules， and the observation group was additionally given modified Huagai powder based on the treatment of the control group. Both groups were continuously treated for seven days. The clinical effect and the remission time of main symptoms and signs were compared between the two groups. Before and after treatment，tidal breathing lung function，indexes of T-lymphocyte subsets in peripheral blood，and levels of inflammatory factors in serum were compared between the two groups. The incidence of adverse reactions was recorded. Results：The total effective rate was 96.00% in the observation group，higher than that of 86.00% in the control group(P＜0.05)；the fever subsidence time as well as the remission time of tachypnea，cough，and the lung rales in the observation group was shorter than that in the control group (P＜0.05). After treatment，tidal volume(Vt)，the ratio of time to peak tidal expiratory flow to total expiratory time (TPTEF/TE)， and the ratio of volume at peak tidal expiratory flow to expiratory tidal volume(VPEF/VE) in the two groups were improved when compared with those before treatment(P＜0.05)；the improvement of the indexes of tidal breathing lung function above in the observation group was better than that in the control group(P＜0.05). After treatment， in the two groups， levels of CD4 + in peripheral blood were increased when compared with those before treatment(P＜0.05)；CD4 +/CD8 + were enlarged (P＜0.05)；levels of CD8+ were decreased(P＜0.05). After treatment，in the observation group，the level of CD4+ was higher than that in the control group(P＜0.05)；CD4+/CD8+ was larger(P＜0.05)；the level of CD8+ in peripheral blood was lower(P＜ 0.05). After treatment，levels of interleukin(IL)- 6，tumor necrosis factor(TNF)- α，and C- reactive protein(CRP) in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the three levels above in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 11.00% in the observation group，and 13.00% in the control group；there was no significant difference being found in the comparison of the incidence between the two groups(P＞0.05). Conclusion： In the treatment of children with influenza viral pneumonia with wind- cold obstructing lung syndrome， the therapy of modified Huagai powder combined with oseltamivir can effectively relieve their symptoms and signs，and protect the lung function. Its mechanism is probably related to positive regulation of T-lymphocyte subsets and down-regulation of expression level of inflammatory factors.