Abstract： Objective： To observe the effect of emotional nursing of Chinese medicine based on routine medical and nursing measures on intervening chronic hepatitis B complicated with emotional disorder. Methods：A total of 120 cases of patients with chronic hepatitis B complicated with emotional disorder of the liver depression and qi stagnation type were randomly divided into the observation group and the control group，60 cases in each group，60 cases in each group. Both groups were given the oral administration of tenofovir tablets and comprehensive nursing measures such as guidance on cognitive education，guidance on lifestyle，and psychological nursing. The observation group was given emotional nursing of Chinese medicine targeted at overactive qi movement and stagnant qi movement both by the lung respectively. Both groups were treated for 16 weeks. Before treatment and after 16-week treatment，scores of Self-rating Depression Scale (SDS)，Self- rating Anxiety Scale(SAS)，and the liver depression and qi stagnation syndrome were evaluated；Trait Coping Style Questionnaire [including positive coping(PC) and negative coping(NC)] was used to evaluate psychological coping；the World Health Organization Quality of Life Assessment- Brief Version(WHOQOL- BREF) was used to evaluate quality of life. Results：After treatment，scores of SAS，SDS，and the liver depression and qi stagnation syndrome in the two groups were decreased when compared with those before treatment(P＜0.01)，and the three scores in the observation group were lower than those in the control group(P＜0.01). The scores of PC in the two groups were increased when compared with those before treatment， and scores of NC were decreased， differences being significant(P＜0.01). The score of PC in the observation group was higher than that in the control group，and score of NC was lower，differences being significant(P＜ 0.01). In the two groups， scores of the three factors of WHOQOL- BREF， namely physiology， psychology， and environment， were increased when compared with those before treatment(P＜0.01)； there was no significant difference being found in the comparison of score of social relation as a factor after treatment and that before treatment(P＞0.05). The scores of namely physiology，psychology，and environment in the observation group were higher than those in the control group(P＜0.01). Conclusion：In the intervention of CHB patients complicated with emotional disorder，emotional nursing of Chinese medicine based on routine medical and nursing measures can improve their negative emotions， lower the frequency of negative coping behavior， relieve symptoms of the liver depression and qi stagnation syndrome， and promote quality of life.