Abstract： Objective： To observe the clinical effect of Zaoren Anshen granules combined with Chinese medicine emotional nursing for middle- aged insomnia of vigorous fire due to yin deficiency type. Methods： A total of 88 cases of patients with middle- aged insomnia of vigorous fire due to yin deficiency type were divided into the study group and the control group according to the random number table method，44 cases in each group．The control group was intervened with routine nursing， and the study group was intervened with Zaoren Anshen granules combined with Chinese medicine emotional nursing. Before and after intervention，the scores of Pittsburgh Sleep Quality Index(PSQI)，Hamilton Anxiety Scale (HAMA) and 36- Item Short Form Health Survey(SF- 36) in the two groups were compared，and the blood pressure values were examined. Results： Before intervention， there was no significant difference being found in the comparison of the scores of PSQI，HAMA and SF-36 between the two groups(P＞0.05)．After intervention，the scores of PSQI and HAMA in the two groups were decreased when compared with those before intervention， and the above scores in the study group were lower than those in the control group(P＜0.05)； the SF-36 scores in the two groups were increased when compared with those before treatment，and the score in the study group was higher than that in the control group(P＜0.05)．Before intervention，there was no significant difference being found in the comparison of blood pressures between the two groups (P＞0.05)． After intervention， blood pressures in the two groups were decreased when compared with those before intervention，and the one in the study group was lower than that in the control group，differences being significant(P＜0.05). Conclusion： Zaoren Anshen granules combined with Chinese medicine emotional nursing for middle- aged patients with insomnia of vigorous fire due to yin deficiency type can improve sleep quality，relieve anxiety and stabilize blood pressure.