Abstract：Objective：To observe the clinical effect of modified Shuihuo Liangbu tang combined with high-quality nursing on diabetic nephropathy(DN) of spleen- kidney qi deficiency type. Methods： A total of 78 cases of DN patients of spleenkidney qi deficiency type were selected and divided into the control group and the observation group according to the random number table method，39 cases in each group.The control group was given routine treatment and basic nursing measures， and the observation group was additionally given modified Shuihuo Liangbu tang and high- quality nursing based on the treatment of the control group.The clinical effect，indexes of blood glucose，indexes of the kidney function，and the score of 36-Item Short Form Survey(SF-36) were compared between the two groups. Results：The total effective rate was 89.74% in the observation group， and 66.67% in the control group， the difference being significant(P＜0.05). Before treatment， when compared levels of fasting blood glucose(FBG)，glycosylated hemoglobin A1c(HbA1c)，serum creatinine(SCr)，blood urea nitrogen(BUN)， and 24- hour urine protein between the two groups， there was no significance being found in the difference(P＞0.05). After treatment，levels of FBG，HbA1c，SCr，BUN，and 24-hour urine protein in the two groups were decreased when compared with those before treatment， and levels of SCr， BUN， and 24- hour urine protein in the observation group were lower than those in the control group， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of each score of SF-36 between the two groups(P＞0.05). After treatment，each score of SF-36 in the two groups was increased when compared with that before treatment，and the scores in the observation group were higher than those in the control group， differences being significant(P＜0.05). Conclusion：The therapy of modified Shuihuo Liangbu tang combined with high-quality nursing has significant clinical effect in the treatment of DN patients of spleen- kidney qi deficiency type，which can improve the level of blood glucose and the kidney function，and promote quality of life.