Abstract： Objective： To observe the clinical effect of Yinzhihuang granules combined with phototherapy intervening pathological jaundice in newborns. Methods： A total of 192 cases of newborns with pathological jaundice were randomly divided into the control group and the experiment group， 96 cases in each group. The control group was intervened with phototherapy，and the experiment group was additionally treated with Yinzhihuang granules based on the treatment of the control group．After treatment，the levels of total bilirubin in serum，the time of clearing jaundice，the clinical effect and the safety in the two groups were compared. Results：The total effective rate was 95.83% in the experiment group and 84.38% in the control group，the difference being significant(P＜0.05)．Before treatment，there was no significant difference being found in the comparison of levels of total bilirubin in serum between the two groups(P＞0.05)．After treatment for three，five and seven days respectively，the levels of total bilirubin in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels at each time point in the experiment group were lower than those in the control group(P＜0.05). The time of clearing jaundice in the experiment group was shorter than that in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 3.13% in the experiment group and 12.50% in the control group，the difference being significant(P＜0.05). Conclusion：Yinzhihuang granules combined with phototherapy has significant curative effect on pathological jaundice in newborns，which can quickly reduce the levels of total bilirubin in serum，and shorten the time of clearing jaundice，withfewer adverse reactions.