宣郁化毒汤辅助肝动脉化疗栓塞术治疗原发性肝癌临床研究
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R735.7

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Clinical Study on Xuanyu Huadu Tang Assisting Transcatheter Hepatic Arterial Chemoembolization for Primary Liver Cancer
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    摘要:

    目的:观察宣郁化毒汤辅助肝动脉化疗栓塞术治疗原发性肝癌的临床疗效以及对血清基质金属蛋白酶-2(MMP-2)和MMP-9 水平的影响。方法:将收治的中晚期原发性肝癌患者98 例,按随机数字表法分为对照组及观察组,各49 例。对照组行肝动脉化疗栓塞术(TACE) 等常规治疗,观察组在对照组治疗方案的基础上给予宣郁化毒汤治疗,每天1 剂,每天2 次。治疗8 周后,比较2 组临床疗效、肝功能以及血清MMP-2、MMP-9 水平。结果:化疗后,2 组谷草转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素(TBil) 均升高,差异均有统计学意义(P<0.01);观察组AST、ALT、TBil 明显低于对照组,差异均有统计学意义(P<0.01)。2 组血清MMP-2、MMP-9 水平均明显低于治疗前,且观察组明显低于对照组,差异均有统计学意义(P<0.01);观察组近期实体瘤疗效总有效率显著高于对照组(P<0.05)。结论:宣郁化毒汤辅助化疗治疗原发性肝癌能改善患者的肝功能,且可抑制血清MMP-2 和MMP-9 水平,提高临床疗效。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Xuanyu Huadu tang assisting transcatheter hepatic arterial chemoembolization for primary liver cancer and its effect on levels of matrix metalloproteinase- 2(MMP- 2) and MMP- 9 in serum. Methods:A total of 98 cases of patients with primary liver cancer in middle and advanced stage who were admitted and treated were divided into the control group and the observation group according to the random number table method, 49 cases in each group. The control group was given routine treatment including transcatheter hepatic arterial chemoembolization(TACE),and the observation group was additionally given Xuanyu Huadu tang based on the treatment of the control group,one dose per day,twice a day. After eight-week treatment,the clinical effect,the liver function, and levels of MMP- 2 and MMP- 9 in serum were compared between the two groups. Results: After chemotherapy, levels of aspartate aminotransferase(AST),alanine aminotransferse(ALT),and total bilirubin(TBil) were increased in the two groups,differences being significant(P<0.01);the three levels above in the observation group were significantly lower than those in the control group, differences being significant(P<0.01). The levels of MMP- 2 and MMP- 9 in serum in the two groups were significantly lower than those before treatment, and the two levels above in the observation group were significantly lower than those in the control group, differences being significant(P<0.01); recently, the short- term total effective rate of curative effect on solid tumor in the observation group was significantly higher than that in the control group(P<0.05). Conclusion: In the treatment of primary liver cancer, the therapy of Xuanyu Huadu tang assisting transcatheter hepatic arterial chemoembolization can improve the liver function,inhibit levels of MMP- 2 and MMP- 9 in serum,and enhance the clinical effect.

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蔡佳吟,罗国庆.宣郁化毒汤辅助肝动脉化疗栓塞术治疗原发性肝癌临床研究[J].新中医,2021,53(11):114-116

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  • 在线发布日期: 2021-06-10
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