Abstract： Objective： To observe and compare the clinical effect and safety of liquid acupotomy therapy guided by ultrasound and by C- arm in the treatment of lumbar disc herniation. Methods： The enrolled patients with lumbar disc herniation were divided into the observation group and the control group，20 and 19 cases in each group respectively. The observation group was treated with liquid acupotomy therapy guided by ultrasound，and the control group was treated with liquid acupotomy therapy guided by C- arm. Both groups were given two- week oral administration of mecobalamin tablets. After medicine treatment，the follow-up lasted for one month. Before surgery as well as on the 1st day after surgery and after follow up for one month， Oswestry dysfunction index(ODI) was used to evaluate the lumbar vertebra function； Visual Analogue Scale(VAS) was used to evaluate the pain degree；duration of operation and frequency of puncture were recorded during the period of liquid acupotomy therapy. Results：After surgery，scores of VAS and ODI in the two groups showed a downtrend，and the two scores on the 1st day after surgery and after follow up for one month were lower than those before surgery，differences being significant(P＜0.05)；in the two groups，the comparison of the two scores and after follow up for one month with those on the 1st day after surgery also showed significance in differences(P＜0.05). No significant differences were found in the comparison of scores of VAS and ODI between the two groups(P＞0.05). The times of puncture in the observation group was less than that in the control group，and the operation time was shorter，differences being significant (P＜0.05). Conclusion：In comparison with liquid acupotomy therapy guided by C-arm，liquid acupotomy therapy guided by ultrasound can lower frequency of puncture，shorten duration of operation，effectively avoid injury of nerve and blood vessel around it，and meanwhile relieve the effect of radiation exposure on medical staff and patients.