Abstract：Objective：To observe the clinical effect of point application with prescriptions based on cold-dissipating and dampness-eliminating method for patients with rheumatoid arthritis(RA) with cold-dampness obstruction syndrome，and its effect on T helper cells 17(Th17)/regulatory T cells(Treg) balance. Methods：A total of 102 cases of RA patients were randomly divided into the control group and the treatment group. The control group was given methotrexate and leflunomide，and the treatment group was additionally given point application with Chinese medicine based on the treatment of the control group ． Scores of Disease Activity Score 28(DAS28) and Chinese medicine syndrome scores before and after treatment were compared between the two groups. Flow cytometry was used to measure the proportion of the expression of Th17 and Treg cells in peripheral blood. Enzyme linked immunosorbent assay was used to determine levels of interleukin- 10(IL- 10) and interleukin- 17(IL- 17) in serum. Results： The total effective rate was 92.31% in the treatment group， higher than that of 76.00% in the control group(P＜0.05). Compared with those in the same group before treatment，joint tenderness number， joint swelling number，scores of Visual Analogue Scale(VAS) and DAS28 of rheumatoid arthritis，erythrocyte sedimentation rate(ESR)，the proportion of Th17 cells in peripheral blood，and the content of IL-17 in serum were decreased(P＜0.05)；the proportion of Treg cells and the content of IL- 10 were increased(P＜0.05). Compared with those in the control group after treatment，joint swelling number，ESR，score of DAS28，the proportion of Th17 cells in peripheral blood，and the content of IL-17 in the treatment group were lower(P＜0.05)；the proportion of Treg cells and the content of IL-10 were higher(P＜ 0.05). Conclusion：For RA patients of cold- dampness obstruction type in active stage，point application with prescriptions based on cold-dissipating and dampness-eliminating method can effectively improve their clinical symptoms and rectify Th17/ Treg cell imbalance in the body．