Abstract：Objective：To observe the clinical effect of mdoified Xiangsha Liujunzi tang and Simo tang on functional diarrhea (FD) with syndrom of liver qi over- restricting spleen and its effect on levels of gastrin(GAS) in serum， motilin(MTL) and vasoactive intestinal peptide(VIP) in plasma. Methods：A total of 72 FD patients with syndrome of liver qi over-restricting the spleen were selected and divided into the control group and the treatment group according to the random number table method， 36 cases in each group. The control group was treated with trimebutine maleate tablets combined with bifidobacterium tetra-live tablets，and the treatment group was treated with modified Xiangsha Liujunzi tang and Simo tang. The clinical effect，levels of gastrointestinal hormone and scores of clinical symptom in the two groups were compared before and after treatment. Results：The total effective rate was 91.67% in the treatment group，significantly higher than that of 66.67% in the control group，the difference being significant(P＜0.05). After treatment，the levels of GAS in serum in both groups were increased when compared with those before treatment(P＜0.05)，the levels of MTL and VIP in plasma in both groups were decreased when compared with those before treatment(P＜0.05)；the levels of GAS in serum in the treatment group was higher than that in the control group(P＜0.05)，the levels of MTL and VIP in plasma in the treatment group were lower than those in the control group(P＜0.05). The scores of abdominal pain，abdominal distension and diarrhea and the total scores of symptoms in both groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the treatment group were lower than those in the control group(P＜0.05). Conclusion： The therapy of modified Xiangsa Liujunzi tang combined with Simo tang can improve the clinical symptoms of FD patients with syndrome of liver qi over-restricting the spleen and regulate the level of gastrointestinal hormone，whose therapeutic effect is better than that of western medicine.