Abstract：Objective：To observe the clinical effect of modified Huanglong tang combined with routine western medicine for senile patients with sepsis complicated with gastrointestinal dysfunction. Methods：A total of 60 cases of senile patients with sepsis complicated with gastrointestinal dysfunction were divided into the control group and the experiment group according to the random number table method， 30 cases in each group． The control group was given routine western medicine，and the experiment group was additionally given modified Huanglong tang based on the treatment of the control group． After seven- day treatment， grading of acute gastrointestinal injury(AGI) of severe patients was observed and compared in the two groups before and after treatment；scores of Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ) and Sequential Organ Failure Assessment(SOFA) as well as nutritional status were observed and compared in the two groups before and after treatment． Before treatment as well as on the 3rd and 7th day after treatment， changes in levels of interleukin-6(IL-6)，interleukin-10(IL-10)，tumor necrosis factor-α(TNF-α)，and C-reactive protein(CRP) in serum as well as levels of leukocyte in peripheral blood were observed and compared in the two groups．During the first three days after treatment， the first defecation was recorded. On the 28th day after enrollment in both groups， the death rate and the incidence of adverse reactions were recorded. Results：On the 7th day after treatment，AGI grading in the two groups was significantly improved when compared with that before treatment，and the improvement in the experiment group was better than that in the control group，differences being significant(P＜0.05)．On the 7th day after treatment，scores of APACHE Ⅱ and SOFA in the two groups were decreased when compared with those before treatment(P＜0.05)，and the two scores in the experiment group were lower than those in the control group(P＜0.05)．On the 3rd and 7th day after treatment，levels of IL- 6，leukocyte，and CRP in the two groups were decreased when compared with those before treatment(P＜0.05)，and the three levels in the experiment group were lower than those in the control group(P＜0.05)． On the 3rd and 7th day after treatment， levels of TNF- α in the two groups showed a downtrend， but there was no significance in differences when compared with those before treatment(P＞0.05)． On the 3rd day after treatment， levels of IL- 10 in the two groups were increased when compared with those before treatment(P＜0.05)，but there was no significance in the difference between the two groups(P＞0.05)．On the 7th day after treatment，level of IL-10 in the experiment group was decreased when compared with that before treatment(P＜0.05)，and the level was lower than that in the control group(P＜0.05)；level of IL- 10 in the control group was still increased when compared with that before treatment，the difference being significant(P＜0.05)．After treatment， levels of albumin(Alb) and prealbumin(PA) in the experiment group were increased when compared with those before treatment(P＜0.05)， and the two levels were higher than those in the control group(P＜0.05)． On the 7th day after treatment，level of Alb in the control group showed an uptrend，but there was no significance in the difference(P＞0.05)； level of PA was decreased when compared with that before treatment，the difference being significant(P＜0.05). During the first three days after treatment，the defecation rate was 76.7% in the experiment group，and 46.7% in the control group， the difference being significant(P＜0.05)． The death rate was 6.7% in the experiment group， and 30.0% in the control group， the difference being significant(P＜0.05)． Conclusion： The therapy of modified Huanglong tang combined with routine treatment can enhance clinical effect in the treatment of senile patients with sepsis complicated with gastrointestinal dysfunction．It can effectively improve gastrointestinal function，reduce release of inflammation mediator，regulate release of anti-inflammatory mediator，enhance immune function of body and promote prognosis.