Abstract： Objective： To observe the effect of modified ChaihuShugan powder combined with acupuncture based on cognitive behavioral therapy，for sub-health insomnia of liver depression and qi stagnation type. Methods：A total of 70 cases of patients with sub-health insomnia of liver depression and qi stagnation type were randomly divided into the control group and the experiment group， 35 cases in each group. Both groups were treated with cognitive behavioral therapy； the experiment group was additionally treated with modified ChaihuShugan powder combined with acupuncture； both groups were treated for four weeks. Before and after four weeks treatment，Sleep quality was evaluated by Pittsburgh Sleep Quality Index(PSQI)，and life quality was evaluated by the World Health Organization Quality of Life Brief Version(WHOQOL-BREF). Chinese medicine syndrome score was evaluated，and the clinical effect was compared between the two groups. Results： After four-week treatment，the clinical effect in the experiment group was better than that in the control group(P＜0.05). The PSQI scores in the two groups were decreased when compared with those before treatment，and the scores of WHOQOLBREF were increased，differences being significant(P＜0.05). The PSQI score in the experiment group was lower than that in the control group，and the WHOQOL-BREF score was higher than that in the control group，differences being significant(P＜ 0.05). When compared scores of physical health，psychological health，social relationships，and environment in WHOQOLBREF in the two groups were increased when compared with those before treatment(P＜0.05)，and the scores of physical and psychological domains in the experiment group were higher than those in the control group(P＜0.05). Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score in the experiment group was lower than that in the control group(P＜0.05).Conclusion：Based on cognitive behavioral therapy， the therapy of modified ChaihuShugan powder combined with acupuncture can effectively improve quality of life， relieve clinical symptoms of Chinese medicine and sleep quality of patients with sub- health insomnia of liver depression and qi stagnation type，with significant curative effec