Abstract：Objective：To observe the clinical effect of modified Zhenwu tang and Xuefu Zhuyu tang combined with Shenqi Fuzheng injection for coronary artery disease complicated with heart failure. Methods： A total of 70 cases of patients with coronary artery disease complicated with heart failure were selected and divided into the observation group and the control group according to the random number table method，35 cases in each group．The control group was treated with standard scheme for internal medicine of western medicine，and the observation group was additionally treated with modified Zhenwu tang and Xuefu Zhuyu tang combined with Shenqi Fuzheng injection based on the treatment of the control group．The clinical effect，indexes of the heart function，and levels of N-terminal pro B-type natriuretic peptide(NT-proBNP) were compared between the two groups. Results： The total effective rate was 97.14% in the observation group and 82.86% in the control group，the difference being significant(P＜0.05)．Before treatment，when compared left ventricular ejection fraction(LVEF)， left ventricular end-systolic volume(LVESV) and left ventricular end-diastolic volume(LVEDV) between the two groups，there was no significance being found in the difference(P＞0.05)．After treatment，LVEF in the two groups was increased when compared with that before treatment，and LVESV and LVEDV were decreased； the increase of LVEF as well as the decrease of LVESV and LVEDV in the observation group was larger than that in the control group，differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of NT- proBNP in serum between the two groups(P＞0.05)．After treatment，levels of NT-proBNP in serum in the two groups were decreased when compared with those before treatment，and the decrease in the observation group was larger than that in the control group， differences being significant(P＜0.05). Conclusion： In the treatment of coronary artery disease complicated with heart failure，the therapy of modified Zhenwu tang and Xuefu Zhuyu tang combined with Shenqi Fuzheng injection can improve the clinical effect and the heart function．