Abstract： Objective： To observe the clinical effect of Guizhi Xinjia tang for cervical spondylotic radiculopathy with deficiency of nutrient and blood syndrome. Methods：A total of 60 cases of patients with cervical spondylotic radiculopathy who were admitted and treated were randomly divided into two groups，30 cases in each group. The control group was given the oral administration of celecoxib capsules and mecobalamin tablets， and the observation group was given the oral administration of Guizhi Xinjia tang. Both groups were treated for two weeks. Before treatment，after treatment，and during the follow- up three months after treatment， the score of Visual Analogue Scale(VAS) for evaluating pain and Chinese medicine syndrome score were compared between the two groups. Results： After treatment， the comparison of improvement in VAS score within the group showed significance in differences(P＜0.05)；there was no significant difference being found in the comparison of the improvement between the two groups(P＞0.05). In the observation group， when compared improvement in VAS score during the follow-up three months after treatment with that after treatment，there was no significance in the difference(P＞0.05)；in the control group，when compared the improvement between the two periods above， there was significance in the difference(P＜0.05). After treatment， the comparison of improvement in Chinese medicine syndrome score within the group showed significance in differences(P＜0.05)；the improvement in the observation group was better than that in the control group，the difference being significant(P＜0.05). In the observation group，when compared improvement in Chinese medicine syndrome score during the follow- up three months after treatment with that after treatment， there was no significance in the difference(P＞0.05)； in the control group， when compared the improvement between the two periods above，there was significance in the difference(P＜0.05). The total effective rate of clinical effect was 83.3% in the observation group，and 76.7% in the control group；there was no significant difference being found in the comparison of the rate between the two groups(P＞0.05).Conclusion：Guizhi Xinjia tang has a good clinical effect in the treatment of cervical spondylotic radiculopathy with deficiency of nutrient and blood syndrome， whose long- term effect is better than that of simple western medicine.