Abstract： In order to enlarge the clinical application of Wuling powder，clinical application of Wuling powder is summed up through analysis of Wuling powder treating Sjogren syndrome， acute cerebral infarction complicated with neurogenic bladder， nephrolithiasis complicated with hydronephrosis， and benign positional vertigo， as well as analysis of Wuling powder in the prescription of Qingfei Paidu Tang in the treatment of Corona Virus Disease 2019． Induced by inhibited qi transformation and impairment of fluid distribution， disturbances of transportation and metabolism of watery humors are manifested by water retention in a part inside the body，or fluid accumulation in the bladder．In the case of the disturbances above，Wuling powder can be used to transform qi and distribute fluid，disperse fluid retention from the upper and the lower separately， and release the interior and the exterior， even though there is no fever， floating pulse， and other exterior syndromes. The pathologenesis of diseases mainly treated with Wuling powder is summarized as impairment of fluid distribution and inhibited qi transformation．Therefore，prescription of Wuling powder can be applied to regulating metabolism of fluid and humor in the body．