Abstract：Objective：To observe the effect of Chinese medicine emotional nursing on negative emotions，quality of life and immune function in patients with initial hemodialysis. Methods：A total of 98 cases of patients with initial hemodialysis were divided into the observation group and the control group according to the random number table method，49 cases in each group. The control group was given routine nursing，and the observation group was given Chinese medicine emotional nursing. Before and after nursing，the levels of immunoglobulin including IgM，IgG and IgA as well as T lymphocyte subsets including CD8+ and CD4+ in the two groups were compared；quality of life was evaluated by World Health Organization Quality of Life assessment(WHOQOL- 100)； negative emotions were assessed by Self- rating Depression Scale(SDS) and Selfrating Anxiety Scale(SAS). Results： Before nursing， there was no significant difference being found in the comparison of levels of IgM， IgG and IgA between the two groups(P＞0.05). After nursing， the levels of IgM， IgG and IgA in the two groups were increased when compared with those before treatment， and the levels in the observation group were higher than those in the control group，differences being significant(P＜0.05). Before nursing，there was no significant difference being found in the comparison of levels of CD8+ and CD4+ between the two groups(P＞0.05). After nursing，the level of CD8+ in the observation group was lower than that before nursing and that in the control group， and the level of CD4 + in the observation group was higher than that before nursing and that in the control group(P＜0.05)，and the level of CD4 + in the control group was higher than that before nursing(P＜0.05). Before nursing，there was no significant difference being found in the comparison of scores of SDS and SAS between the two groups(P＞0.05). After nursing，the scores of SDS and SAS in the two groups were decreased when compared with those before nursing，and the scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). After nursing， the score of quality of life in the observation group was higher than that in the control group，the difference being significant(P＜0.05). Conclusion：Chinese medicine emotional nursing can effectively improve immune function，quality of life and negative emotions in patients with initial hemodialysis with high clinical values.