Abstract： Objective： To observe the curative effect of Baiji Sanhuang powder combined with loop electrosurgical excision procedure(LEEP) for high-grade cervical intraepithelial neoplasia(CIN). Methods：A total of 60 cases of fertile women with CIN grade Ⅱ or Ⅲ without interstitial infiltration were randomly divided into the control group and the treatment group， 30 cases in each group. The treatment group was given Baiji Sanhuang powder on the cervix after LEEP， and the control group was not given special treatment after LEEP. The postoperative curative effect in the two groups was observed and compared. Results：After treatment，vaginal discharge time，bleeding time，amount of bleeding，wound healing time of cervix and incidence of postoperative vaginitis in the treatment group were significantly lower than those in the control group(P＜0.05，P＜0.01). Three and six months after surgery respectively，the Human papillomavirus(HPV) positive rates in the treatment group were lower than those in the control group(P＜0.05)；there was no significant difference being found in the comparison of review results of cytopathology between the two groups(P＞0.05). Conclusion： After LEEP， Baiji Sanhuang powder given to cervical wounds can promote the healing， reduce the adverse reactions such as vaginal discharge，wound bleeding and infection，and significantly improve the negative conversion rate of HPV.