Abstract：Objective：To observe the clinical effect of Kushen Tang Combined with Routine Westine Medicine for chronic eczema. Methods：A total of 72 cases of patients with chronic eczema were selected and divided into the observation group and the control group according to the random number table method，36 cases in each group. The control group was treated with routine western medicine， and the observation group was additionally treated with medicated bath with Kushen tang based on the treatment of the control group. The levels of immune function and inflammatory factors before and after treatment in the two groups were compared；the clinical effect was evaluated. Results：The total effective rate was 86.11% in the observation group， and 63.89% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of CD4 + ， CD8 + and CD4 +/CD8 + between the two groups(P＞0.05). After treatment，the levels of CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment，and the levels in the observation group were higher than those in the control group(P＜0.05)；CD8+ levels in the two groups were decreased when compared with those before treatment，and the level in the observation group was lower than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of interleukin- 2(IL-2) and interferon-γ(IFN-γ) between the two groups(P＞0.05). After treatment， the levels of IL-2 and IFN-γ in the two groups were decreased when compared with those before treatment，and the levels in the observation group were lower than those in the control group(P＜0.05). Conclusion： Kushen tang combined with routine western medicine for chronic eczema can effectively improve the clinical symptoms of patients，regulate the immune function，inhibit inflammatory factors，with good overall effect.