Abstract：Objective：To observe the clinical effect of Baogan Jiangzhi prescription combined with silybin for metabolism fatty liver disease(MAFLD) of internal retention of dampness turbidity type and its effect on liver function and blood lipid levels. Methods： A total of 140 cases of MAFLD patients with internal retention of dampness turbidity type were divided into the control group and the observation group according to the random number table method，70 cases in each group. The control group was treated with silybin combined with reasonable diet， appropriate exercise， and control of body weight； the observation group was additionally treated with Baogan Jiangzhi prescription based on the treatment of the control group. Both groups were treated for three months. Before and after treatment，the Chinese medicine syndrome scores，liver function indexes and blood lipid levels in the two groups were compared. The clinical effect in the two groups was compared. Results： After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the score in the observation group was lower than that in the control group(P＜0.05). The total effective rate was 92.86% in the observation group， higher than that of 80.00% in the control group(P＜0.05). After treatment，the levels of alanine aminotransferase(ALT)，aspartate aminotransferase(AST) and γ-glutamyl transferase(GGT) in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above levels in serum in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of total cholesterol(TC)， triglyceride(TG) and low density lipoprotein cholesterol(LDL- C) in the two groups were decreased when compared with those before treatment(P＜0.05)，high density lipoprotein cholesterol(HDL-C) levels were increased(P＜0.05)； the levels of TC， TG and LDL- C in the observation group were lower than those in the control group(P＜0.05)， and the HDL- C level was higher(P＜0.05). Conclusion： Baogan Jiangzhi prescription combined with silybin for MAFLD of internal retention of dampness turbidity type can improve clinical symptoms，liver function and blood lipid levels of patients.