Abstract： Objective： To observe the clinical effect of Yangfei Yishen granules in treatment of chronic obstructive pulmonary disease(COPD) with syndrome of qi-yin deficiency in lung and kidney at stable stage，and its effect on levels of monocyte chemoattractant protein-1(MCP-1)，interleukin-2(IL-2)，and interleukin-10(IL-10) in serum. Methods：A total of 60 cases of COPD patients with syndrome of qi-yin deficiency in lung and kidney at stable stage were selected and divided into the Chinese medicine group，the western medicine group and the control group according to the random number table method， 20 cases in each group. The control group was given routine treatment， the western medicine group and the Chinese medicine group were additionally given theophylline sustained- release tablets and Yangfei Yishen granules respectively based on the control group. All groups were treated for 28 days. Clinical effect and levels of MCP-1，IL-2 and IL- 10 in serum as well as the scores of Chinese medicine syndrome before and after treatment in the three groups were compared. Results： After treatment, the score of Chinese medicine syndrome in the three groups were decreased when compared with those before treatment(P＜0.01)； the scores of Chinese medicine syndrome in the Chinese medicine group were lower than those in the western medicine group and the control group(P＜0.01). After treatment，the scores of cough in the three groups were decreased when compared with those before treatment(P＜0.01)；the comparison of the cough scores among the three groups showed significance in the difference(P＜0.05)，and the score in the Chinese medicine group was lower than that in the control group(P＜0.05). After treatment， the scores of chest distress in the three groups were